Milan’s 5Vie district is among the city’s most design-conscious, perhaps never more so than this time of year, when tens of thousands visit the city for Milan Design Week. An essential stop on their itineraries will be L’Appartamento, an apartment in a historic 1930s building with interiors reimagined by six preeminent designers—each utilizing furnishings and art selected from the Artemest network of brands and makers.

Just past a set of yellow-and-blue colored glass windows, T.ZED offers a textured entryway, while Paris’ Anne-Sophie Pailleret groups visionary furnishings and sculptural lighting, announcing to visitors that L’Appartamento is firmly facing the future. Kingston Lafferty Design then takes them on a journey into the Living Room, while MONIOMI Design brings a touch of Miami heat to the terrace. In the dining room, Nina Magon plumbs the contours of monochromatic design, while Styled Habitat’s Rabah Saeid returns to the apartment’s 1930s roots with an Italianate bedroom that artfully dodges period pieces.